Video Game Cruelty Potential/Web Comics

Leo, of VG Cats, is a Cruel Player Character God, as seen here.
El Goonish Shive. Tedd can be quite cruel when playing Black and White, though apparently not to the extent suggested above.
- He mostly seems to turn people into girls. So it's more or less like his usual behavior, but more.
- If memory serves, it's Grace who goes overboard with this. 'That poor turtle..'
And now Gabe joins the fun with In Famous.
Brawl in the Family points out just how cruel standard gameplay is in its "Ode to Minions".
In Hearts of Iron, you can launch a nuclear attacks. Not only will the target country suffer industry and manpower destruction, it may well descend into civil war.
In a bonus comic for Gunnerkrigg Court, Kat introduces Annie to Grand Theft Auto. Annie, who apparently hasn't played computer games before, has trouble sleeping that night...
Homestuck's Sburb has a lot of potential for this. Case in point. The entire reason why that situation exists is because of their version of live action role-playing - Vriska (the girl he's talking to) used her powers as a Killer DM to force Tavros (the guy in the wheelchair) to jump off a cliff when he was indecisive about fighting two powerful enemies.
Darwin Carmichael Is Going to Hell has a strip where Skittles the manticore is upset when Patrick shows him how to play Grand Theft Auto.