The Killers/Tear Jerker

Though most of their songs by this indie rock band are pretty upbeat, there are a few here and there that can trigger the tears.

"Goodnight, Travel Well" is a notable example, in that the lead guitarist after his mother died of cancer. And then, over a year after the album came out, the songwriter Brandon Flower's mother died of brain cancer as well.

"Everything you loved, and every time you try,
Everybody's watching, everybody cry.
Stay, don't leave me, the stars can wait for your sign, don't signal now."

"Read My Mind" is very powerful, and is Brandon's favorite song that he's made.
One might tear up upon hearing "Mr. Brightside", which is pretty angtsy in itself -- especially upon listening to the song after saying many sad goodbyes to a bunch of really good friends who are graduating high school.
The music video for "A Dustland Fairytale" is both a tearjerker AND a CMOA for The Killers. As is the song itself.
- "Human".

"Will your system be alright
When you dream of home tonight?"

Then there is their rendition on Dire Straits' "Romeo and Juliet". See under Dire Straits in Tear Jerker/Music/Rock Music for more info.
"Tidal Wave" is a tearjerker of heartwarming variety.
"Why Do I Keep Counting?" is all about a suicidal man begging for help. The ending lyrics are especially rough for anyone who's suffered from severe mental illness.

"If I only knew the answer
If I change my way of living
And if I pave my streets with good times
Will the mountain keep on giving?
And if all of our days are numbered
Then why do I keep counting?"

The climax and coda of "Andy You're A Star" with the chorus singing in the background is such an uplifting feeling from the rough and rugged guitar lick repeated during the first two verses. You can't help but feel moved and teary-eyed at that moment.
"Believe Me Natalie", anyone?