Palom and Porum'sHeroic Sacrifice in Final Fantasy IV. It was bad enough in the original game, but Ron characterized them much more, and made constantly mentioned how fun it was to be around them. It is also one of the only times that Ron acts not only calm, but very much concerned.
It would be impossible to spoiler the entire exchange without making this entire page look hideous, so beware of spoilers.
Ron: Wait... you guys... Palom, Porum there... Let's go save them... Cecil: It's right here. Cid: Yep, right under their noses! Ron: Wait, you guys... come on... Cecil: Kid, it's hard to tell you this... but they're gone... Ron: No, they're not gone! Palom, Porum. They're alive! I know it! Come on! You guys... *through tears* they were my best friends. Hey! You guys! Listen to me! Yang! Tella! Cid! *skips dialogue without reading it*< Cid: Sorry to keep you waiting, Enterprise. Let's go. Sir Ron Lionheart, get over it. They're gone. They're gone, I tell you. Ron: No, they're not gone! They're not gone! We're going back! We're going to try to save them! *ship takes off* Okay, I don't care what's happening right now! We're going to save Palom and Porum! Cecil: Trust me kid, there's nothing we can do. Ron: Well, we'll save them in the next episode. This is Sir Ron *stops to cry* Lionheart. Signing out. Man... Palom and Porum! You guys... Cecil: Good grief... Ron: You guys... well, farewell everyone...