Flanderization/Real Life

Examples of Flanderization in Real Life include:

Alzheimer's disease at some stages may bring some traits out of its victims and exaggerate them to the extreme.
Sports broadcasters and a lot of radio personalities do this to themselves as time goes on. Chris Berman, Tony Kornheiser, Dick Vitale, Jim Rome all immediately come to mind as people that have particular quirks that are used more and more as they continue - in some cases, their knowledge hasn't grown so they cover it up with their personality.
Severe Personality Disorders and some chronic forms of schizophrenia can cause this, as the pre-existing personality gets constricted to a few very specific mindsets and behaviors, losing its natural "dynamicity". Affected individuals are usually seriously debilitated and have massive problems adapting to different situations. However, milder forms of these conditions exist where the "personality constriction" is less obvious, while fiction usually portrays only the most severe manifestations, giving off the impression that every affected individual is like this.
- Similarly, certain developmental disorders like autism play with this trope, as in some cases a particular restricted interest can become so all-consuming that it dominates their whole life, and the affected individual literally forgets about anything else. However, media depictions of autistic characters tend to prefer such extreme manifestations, and thus fictional autistic characters are often Flanderized when compared to more average, real-life autistic people.