Ends of the Earth

He'll go to the ends of the Earth to protect you

The major Spider-Man storyline of 2012, and part of the 50th anniversary of Spider-Man's first appearance.

Otto Octavius is dying. Thanks to the various injuries suffered in fights against Spider-Man, Captain America and others, Doctor Octopus has found his body failing him and after months of failing to find a cure, he has instead decided to focus on the legacy he will leave behind - Otto Octavius has found a way to stop Global Warming. Supposedly. Spider-Man doesn't trust him, for good reason. If Octavius is lying or not is irrelevant - he's holding the world hostage with his dying breath.

What price will Spider-Man have to pay to stop him & buy the world another day?

What if Doctor Octopus is telling the truth?

Tropes used in Ends of the Earth include:

Avengers Assemble
Big Bad: Doctor Octopus
Crazy Prepared: Spider-Man debuts a new set of Spider-Armor, designed specifically to combat the Sinister Six, and brings a team of Avengers specifically selected to match the Sinister Six. Unfortunately, Doc Ock is several moves ahead.
Dude, Where's My Respect?: After the UN dismiss Spider-Man's warnings about Octavius out of hand, Thor steps in.

Thor: I am Thor Odinson, heir to the lord of Asgard, and this man is my most trusted counsel.

Enemy Mine/Heel Face Turn: Mysterio turns on Ock when Spider-Man points out that for all of Mysterio's loyalty to Octavius, if Spider-Man's right about Ock, then Mysterio's going to burn with the rest of the world & the two billion dollars that the Sinister Six were each given will be worthless.
Fighting Your Friend: Spider-Man & Black Widow are forced to fight the rest of the Avengers after Ock uses his Octo-bots to turn them into mindless drones.
It's All My Fault: Said verbatim by Spider-Man's inner-monologue when he realises that all of Octavius's "tech" are just perversions of things Peter had created at Horizon Labs.
Nice Job Fixing It, Villain: Spider-Man, Silver Sable & Black Widow were going to fight Doc Ock to the bitter end, unaware it was really Chameleon in a Doc Ock suit, until the real Otto took over & clued them in it was that was just an imposter.
Oh Crap: Spider-Man when he realises that for all of his prep for the Sinister Six, Ock is still several moves ahead of him.
Only Sane Man: Spider-Man, the Avengers and the folks at Horizon Labs, are seemingly the only ones who realise that Octavius is lying. Maybe.
Ship Tease: First with Silver Sable and Spidey, and later with Mary Jane keeping Peter in her thoughts while planning a homecoming party for him
Take That: Spider-Man punches out Al Gore. Granted, it's really the Chameleon in disguise, but still. There's a reason why Marvel released the first pages of the issue.