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* ''[[Homestuck]]'' - Sollux is a high-level psionic. The mind honey which boosts his lusus from idiocy completely [http://www.mspaintadventures.com/?s=6&p=004053 overloads] his brain when he eats it.<ref>YOU DO NOT UNDER ANY CIRCUMSTANCE EAT THE MIND HONEY</ref> He recovers, but there are terrible consequences.
* ''[[Schlock Mercenary]]'' has the Bradicor — aliens found on a backworld planet. The collapse of the civilization nearly a million years ago was due to their experiments with immortality, specifically replacing the brain with more resilient and self-repairing material (the rest is straightforward body repair via medical [[Nanobots]]). Unfortunately, their species' brain architecture wasn't up to handling memories accumulated long past their natural lifespan, so they began to go insane due to too many days going by too similar for the mind to sort out. The only ways to avoid it were [[Brain Uploading]] into less organic computers or installing selective amnesia to live on in permanent state of mild senility. The former worked until they had [[Mutually Assured Destruction]] go past assurances (which was even easier, since all those mainframes were stationary), the latter made the survivors an obscure relict living mostly as primitive hunters-gatherers.
* ''[[Girl Genius]]'' has the "Queen's Hedge", a hidden off-site backup created by Her Undying Majesty Albia, the [[God-Emperor|Eternal God-Queen]] of England for her permanent memories. As her trusted
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