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* In 2008's ''[[The Incredible Hulk (film)|The Incredible Hulk]]'', the source of the Abomination's powers is a double dose of the Marvel Universe's fabled Rebirth Project super-soldier serum , combined with a blood transfusion from Bruce Banner. This appears to have been done as part of an effort to provide visible ties between Marvel Studios' adaptations of their canon characters - in this case, laying groundwork for the ''[[Captain America: The First Avenger|Captain America]]'' film.
** Actually, even Banner's mutation into the Hulk in the [[Marvel Cinematic Universe]] is due to his experimentation with the original serum. A combination of the fact that he didn't know what he was doing (the military had told him the work was for radiation resistance) and his replacing [[Techno Babble|Vita-Rays]] with Gamma radiation led to his transformation.
* In the [[The Bowery Boys||Bowery Boys]] movie ''Hold That Line'', Sach mixes a bunch of random chemicals together and drinks down the mixture. The potion turns Sach into a super-athlete. Inverted later in the movie when Slip tries to replicate the formula. Slip gives the potion to the college Dean, who {{spoiler|shrinks in size}}.
* In the 2011 movie ''Limitless'' the main character uses a drug to become super smart.
* After defeating his arch-nemesis Metro Man, [[Megamind]] decides to give Metro Man's superpowers to a random guy who would become the next champion of Metro City. He extracts Metro Man's DNA from some dandruff on his cape and accidentally injects it into {{spoiler|Hal the cameraman}}.
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