The Middle/WMG

Sue's going to be the most successful of the three
Y'know how Karma's a bitch, right? Well, it works the other way around when you're pretty much the biggest Chew Toy ever.
 * And then in college she will run into Malcolm. After realizing they are Opposite Sex Clones they will join forces to fight crime.
 * That would be an awesome TV show.

The whole series is actually a TV show created by...
an adult Dewey. In order to cope with the insanity of his childhood, he decided to create a whole series based around it. Of course, he changed a few things like the names(he even wrote a daughter in!)as not to embarass his real family.

Brick is autistic.
He does seem to manifest some of the characteristic signs of Asperger syndrome, a high-functioning form of autism.
 * The Fire Blogger would be proud.

After Brad finally realizes he's gay
Sue will gladly become his Fag Hag slash BFF.

Dewey and his youngest brother had created The Middle
Dewey and Jamie bonded their minds just as the series was over, entering a polar opposite of both family and friends. Dewey developed into Brick while Jamie matured into Axl. Reese's prank was a mark elaborated by Dewey and Jamie to choose who exists in this new universe. Sue is Lois as a child who's actually happy. Mike the perfected version of Hal. Frances is a younger Aida, a perpetually young woman chosen to happen because of Aida's attempt to rescue Dewey.

Zach Braff will appear as Mike's nemesis.
He'll be an immature, obnoxious rival construction site owner. Why? Because both Doris Roberts and Ray Romano have appeared in Actor Allusion cameos for Patricia Heaton. It'd be funny if Neil Flynn got the same.

The Glossners are how the rest of their neighbours see Malcolm's family
Sons terrorise at will? Check. Social pariahs? Check. Mother often hostile? Check! Their ages are even roughly representative of Malcolm and his brothers, minus Francis but with Jamie. Of course, they're not really that bad, but they're still as rightly feared.