Crystal Castles (band)/YMMV

For the musical duo:
 * Crowning Music of Awesome: "Not in Love (ft. Robert Smith)" definitely counts. Robert Smith of The Cure on vocals, Alice Glass' breathy ones joining in at the bridge, and Ethan Kath's newly polished production skills really make it for this one.
 * "Alice Practice", the song that introduced them to the world. Basically what would happen if you captured a chiptune band and a female-fronted hardcore punk band and made them fight. It's glorious.
 * Hell Is That Noise
 * Tear Jerker: "Tell Me What to Swallow"

For the video game: