Two Guys and Guy/YMMV


 * Crazy Awesome: Frank, who experiments on aliens, other humans and unstable matter, has a back-up twin factory of Wayne, a portal to a mirror dimension, a degree in applied pseudo-science and is frequently armed for no apparent reason.
 * Magnificent Bastard
 * Designated Heroes
 * Ho Yay: Why does Frank know that?
 * Ninja Pirate Zombie Robot: Over the course of the comic, Wayne's become a were-chiuahua, vampire, zombie, ghost, robot, and irradiated mutant... assuming it was the same Wayne in all of those strips.
 * Jerkass Woobie: Assuming you choose to feel bad for Wayne.