Ojamajo Doremi/Tear Jerker


 * Ojamajo Doremi seemed to have at least two of these a season -- the second movie even ended in a heartbreaking Tear Jerker... and appropriately enough, it factored into Aiko's goal to reunite her parents late in Dokkan. Runner up is a 3 way tie between the Motto Christmas Episode, Littlest Cancer Patient Non-chan in Naisho episode 12, and the series finale.
 * The entire twelfth episode from Naisho is a big Tear Jerker. To drive The whole thing was so unbearably sad, especially since . I Think I need to lie down for a minute...
 * Tear Jerker: Aiko's attempts to get her parents back together, Hazuki's borderline freak out over the incident with Nanako and her bunny, Momoko's backstory (which comes back with a vengeance at the end of Motto) among other moments
 * Actually, the series contains tons of Tear Jerker, some of them among the most well done emotional anime-scenes, this troper has ever seen. I am convinced that no human being should be able to watch the last episode of Sharp without bursting into tears. Also, the two last episodes of Naisho feature character death in it's most heartwrenchingly sad form.