Lollipop Chainsaw/WMG

Nick (severed boyfriend head) will temporarily gain a body and become a boss at some point
Suda'd do it. He's crazy like that. Plus it could work as another to Buffy shout-out.
 * Confirmed (To some extent)in the newest trailer. Juliet can put his head on a headless body so he can give help her out. (So far we've only seen him giving her a boost when she needs to reach a higher place)

Juliet is the grown-up Bubbles
A twin-tailed blond with a fondness for all things cute and sweet with the capability to solve problems with violence when the situation calls for it. It could happen. There's also their other connection, and while we're on that subject...

Juliet is an alternate-universe Ember
The DP version (presumably) killed herself when her boyfriend dumped her. The Suda version cut his head off and accessorizes with it as she kills zombies.

Juliet is a cousin of Travis Touchdown
Hey, we know Travis' dad was a cheating scumbag. Jeane might not be Travis' only relative he has no idea he has.

The game takes place in the same universe as Dead Rising
Similar zombie outbreak, same level of silliness, and similar characters. Who knows, maybe Juliet is the daughter of Frank West?