Pharaoh/YMMV


 * Demonic Spiders:
 * Hippos and Crocodiles. Hyenas tends to be more like Goddamn Bats instead. The game advises you to send your armies to deal with them. The easier way --the expensive way-- is to build a wall encircling their spawn points.
 * And don't even try sending archers against hippos.
 * Chariot units, when you don't have access to it yourself. Also, the Carthaginians from Caesar.
 * Unwinnable By Mistake: In Saqqara, if you don't praise Ra enough, he might make people sell less stuff to you. Including making the only town selling reed - that you need to import to get papyrus - stop. No sending the grave materials to the pyramid, no winning. And to a less dangerous and more annoying extent, more tiles of houses for the same amount of people.
 * One mission has a city ask you for shipments of limestone, which you produce in great quantities since no one buys it. However, at one point they ask you for plain stone, which you can't mine for, but you can't even import it.