And I Must Scream/Anime

"Ranka: (pets her newest doll, erm, victim): No longer will you age or grow decrepit. You can live forever, looking the way you do now...
 * Pretty Cure:
 * Michiru and Kaoru Kiryuu spend nearly half of Futari wa Pretty Cure Splash Star paralyzed at the bottom of a lake
 * At the start of Yes! Pretty Cure 5, Nuts was trapped inside the then-unopenable Dream Collet.
 * Queen Beryl doomed Jadeite to "eternal restless sleep" in Sailor Moon after his repeated failures. Which meant trapping him in a giant crystal and sealing him away somewhere. It's a very popular starting point for Fan Fiction. And lest you think this is an example of Never Say "Die", Beryl had no qualms with outright killing her failed henchman, leaving this punishment as particularly gruesome in retrospect.
 * Later on, another villain, Mimmete, is transferred into energy in order to enter a computer where her power is amplified...only for a backstabbing cohort to pull the plug on the computer, leaving her trapped as energy inside the computer system forever.
 * 's fate in Naruto. He gets blown into pieces, and buried in a hole... but he's immortal, and his severed head continues to curse Shikamaru right until he's covered over while rotting slowly away from the lack of nourishment. According to the second fanbook he is
 * Itachi
 * This was revealed to happen to
 * This is also the case for every sealed Bijuu.
 * Kakurenbo--While we cannot be sure how aware they are, the children captured by the demons . It gets worse at the very end,.
 * The "winner" of the game.
 * Episode two of Vampire Princess Miyu, "At The Next Station". This is the fate of the women who fall prey to the temptation of the Shinma Rho-Ah, and take him up on his offer of enhanced beauty... only to end up frozen in time, like beautiful mannequins dressed in expensive clothes, never to age or decay... at the end, even the one who got decapitated during the battle between Rho-Ah and Miyu is still alive, just like the rest of them -- whimpering and sobbing quietly through paralyzed lips.
 * In the second OAV, it's downright stated that Ranka's victims end up in a similar state, transformed into bare and listless mannequins that she keeps into her school's warehouse. She even uses one of them as a shield during her fight with Miyu, and Miyu is horrified when Larva accidentally hits the doll with his Razor Floss and not only it emits a whimper of pain, but it bleeds. This is lampshaded earlier, in this conversation that takes place during Ranka and Miyu's first encounter:

Miyu: (steps in) And thus... will the life energy that you emit become my sustenance...!"


 * Ninja Scroll: The immortal, regenerating bad guy gets encased in molten gold, gold which he had schemed and murdered to claim, no less, and sank to the bottom of a lake.
 * This was a punishment dealt to Team Rocket (temporarily, thanks to a between-episodes Reset Button) in an early episode of Pokémon.
 * which episode please?
 * Sabrina's dolls. While they couldn't move or actually talk, it was pretty clear they were conscious. Good thing Ash found a way to beat her.
 * In the Pokémon Special manga's FRLG arc, Silver gets turned into stone along with four other Dex Holders and he alone stays conscious throughout the series until he gets unfrozen along with the rest of them.
 * Art teacher Hitomi Ishigami enjoys doing this to her students in the Rosario to Vampire manga, for the sake of "true art". She picks out girls to be her "models", then Takes Them For Granite and lets them cry as much as they want (their tears stream down their stone faces to get this across).
 * In Bleach, the end of the fight between Mayuri Kurotsuchi and the Espada Szayel Aporro Granz.
 * In Yu Yu Hakusho, Kurama traps in a plant that drains the energy of its victims until they die, while showing them a hallucination of their worst fear... but since the latter can't die, he's stuck seeing his worst fears for eternity.
 * Mukuro's father met a similar fate thanks to a conjoined effort by Kurama and Hiei, the latter of which donated him to Mukuro as a gift. The parasitic plant binds him completely, but also sustains him so long as his head remains intact. So, all he has to do to get out of it is convince her to break his skull open... good luck with that.
 * Jo Jos Bizarre Adventure:
 * In Part 2 of ,the villain Cars ends up gaining immortality and an auto-evolution ability after combining the Stone Mask and Red Stone of Asia. Joseph uses this ability against him by throwing him into an active volcano where he hardens in defense as it's about to erupt. He gets launched into space and is stuck floating around forever, eventually his mind shuts down completely.
 * In Part 5, the Boss Diavolo/King Crimson was struck by Giorno's, which sent him in a mental, eternal loop of deaths, while his body stayed idle, seemingly comatose.
 * In Part 7, Magenta Magenta's power gives him perfect defense, including not needing to breathe, as long as he stays still. Hirohiko Araki has a real thing for this trope.
 * Part 4 has Jouske inflict this punishment to Angelo (Fusing him to a rock, and for kicks, putting a sign saying "Please leave your Dog Crap here" which Angelo HATES) and Miyamoto (Fuses him into a book. It's said that the book became a notable icon of the town, and people can sometimes hear whispers coming from it....). A variant happens with Akira's stand Red Hot Chilli Peppers, which gets trapped inside a tyre and hurled into the sea. Akria does not die, no it can be assumed that Red Hot Chilli Peppers is stuck like that.
 * In the classic Nickelodeon anime The Noozles, the soul of Sandy's grandfather is doomed to spend the rest of eternity trapped inside a crystalline orb in another dimension.
 * In Yaiba we have Dark the Darkness Demon who can use his Delta Zone and Super Delta Zone attacks to engulf his opponents into a dark pyramid and send them into another dimension forever. The victims include.
 * Used for a Karmic Death in Franken Fran. An old, rich woman was seeking to have her youth restored, and had her servants murder any doctor that couldn't come up with a permanent answer. . She hires Fran, who comes up with a treatment that seems to have results... then has her men cut Fran's head off afterwards. Unfortunately for the old woman, Fran is an Artificial Human, capable of stitching her own head back into place. She confronts the old woman afterwards, and notes an unusual rash on her arm...
 * This is a case of Truth in Television as there is a line of immortal human cells born from the cancer cells of a human. Granted, the human they were born from died from the cancer.
 * The Mazoku from Slayers have Raugnut Rushauvna (or however you spell that), a very, very nasty curse that makes its victim completely immortal... while also turning their body inside out and causing it to continually devour itself and regenerate, over and over and over again, for all eternity.
 * Angel Sanctuary has a doubly terrifying version revealed towards the end.
 * Gundam also uses it on occasions. Zeta Gundam might give the idea of Kamille being thrown into one of those (though probably only lifelong) situation at the end, but he gets better in the sequel, Gundam ZZ. Villains like from Victory Gundam or  from Gundam X end up at least in one way or the other crippled ( is blinded and amnesiac,  is wheelchair-bound -- Gundam's not that far into mysticism, so no punishment beyond life so far). Though, Gundam X has  a.k.a. Lorelei (a good minor character) being put in a forced coma and locked in a capsule for 15 years or so, mostly cut off from the real world.  )
 * Anyone who is infected with DG Cells in G Gundam. You either become a zombie used to power the Dark Army, or slowly go insane/rabid.
 * The manga Blood Alone has a killer who can jump to other bodies when he dies. Unfortunately, the last people he fights are a vampire and rather savvy human. She turns him; and then he breaks his neck just as he turns into a vampire. The killer is now frozen in the body of an permanently broken necked vampire. They lock him up in a room in the basement of a hospital.
 * The manga Tokyo Crazy Paradise has a scene in which exhibits on display in cabinets turn out to be human beings, posed like famous works of art. The cabinets contain machinery that keeps their occupants alive and immobile. They are intended for sale to rich collectors who are perfectly aware that the exhibits are alive and helpless, and quite happy to leave them that way. The heroine Tsukasa attempts to free them, but is caught and ends up frozen in a cabinet herself.
 * In one scene in the Elfen Lied manga, there's a diclonius who is not much more than a head and a chest within a completely enclosed metal box. The head is covered by the same helmet and mask as the dicloni in the lab. The diclonius' only purpose is to use its telepathic abilities to sense others of its kind and serves as a biological detector device.
 * Not only that, but a device is connected to the girl's spine to make her experience continuous pain in order to prevent her from lashing out at her tormentors.
 * He also stated that after raping her (before cutting her in half), he cut out her vocal cords. This series doesn't have enough generosity to its characters to do it in a clean way, so you must use your imaginations on how that went.
 * Because that isn't enough, her psychic projection of herself is nothing but a scarred upper-body with a faceless, missphapen head uttering only "It hurts", "Kill me" and "Run" over and over.
 * Fullmetal Alchemist: Greed found himself in this situation in the first anime, sealed in a skull stuck in a wall for hundreds of years,.
 * In the manga and Brotherhood, this happens to.
 * In truth, all of these examples are largely temporary. as . But one example at the very end of the manga and Brotherhood is a permanent version..
 * In Nightmare Inspector,
 * One possible interpretation of in Neon Genesis Evangelion.
 * Yu-Gi-Oh! has this. Characters frequently get their souls taken from them and imprisoned in cards or in the Shadow Realm. No idea what they can feel while they're inside either one.
 * According to the Word of God, Yami was aware of time passing when he was sealed in the puzzle for three thousand years. There's a reason he was not entirely sane when he first awakened.
 * Texhnolyze started off with this and then it just goes downhill from there... ending in what could be referred to by some as Brain Bleach.
 * In Inuyasha, the Shikon no Tama is formed through a miko and a combination of youkai being locked in a battle. The souls of the youkai and Midoriko still battle endlessly inside the jewel, for the 500 years or so of its existence. Near the end of the series,
 * Several truly chilling instances in Mouryou no Hako, the most awful being the fate of
 * There's also
 * In Magical Records Lyrical Nanoha Force, this is the eventual fate of someone who tries to resist the insatiable hunger given by the Eclipse infection. Its Healing Factor will go out of control, and eventually, the infected will be reduced to a lump of flesh similar to those brain-like things in the Abandoned Lab that Lily came from.
 * What happened to in Love is in the Bag, specifically
 * What happened to Kaoru in an early mini-arc in Rurouni Kenshin, thanks to Complete Monster Kurogasa. An extremely Ax Crazy swordsman and hypnotist who wants to fight male lead Kenshin and kidnaps her to force him to, as soon as Kenshin reaches for them Kurogasa hypnotizes the poor girl into complete paralysis. This means, not only she can't move her limbs or talk... but is slowly, painfully and inexorably asphixiating, since her whole respiratory system is under paralysis too. And she's fully conscious, helplessly watching how Kurogasa and Kenshin fight it out and Kenshin is reverting to his Knight Templar Battousai side only to save her, since the only way to break that "spell" is to kill Kurogasa himself before she kicks it...
 * Griffith from Berserk suffers a purely physical, non-supernatural version of this:
 * In Mermaid Saga, it's unclear whether  died or was left petrified and conscious for a hundred years. All that we do know is that her eyes still work. Mana claims that  was dead all along, but it's clear she's just trying to make Yuta feel better.
 * Piedmon suffers this fate near the end of Digimon Adventure, when he's thrown into MagnaAngemon's Gate of Destiny, which according to Word of God leads to a pocket dimension from which there's no escape. And since Digimon are functionally immortal, barring being killed by someone else... since Piedmon was a Complete Monster, this was a well-earned Karmic Fate Worse Than Death.
 * In Bakugan, this was intended to be the fate of by Code Eve, the god of the Bakugan, as punishment for . And she was quite thorough about it..
 * Bakugan sent to the doom dimension suffer from this. The place is so inhospitable that they are forced into a dormant state where all they can do is think about how much they hate their situation, except for Reaper who stays conscious but gets hideously wounded.
 * In Cowboy Bebop, the electronic 'uploading' cult SCRATCH turns out to be led by
 * In Shaman King, Yomi's Hole is a cave where you lose all senses: you can't see or hear anything, and you enter some kind of existential panic; we actually see what it's like when Ryu enters it for just a minute. It has been mentioned that many young shamans wanting to enhance their furyoku lost their sense of direction inside and stayed the rest of their lives in there.
 * Baccano has a lot of immortal characters, and a couple of them end up like this. Perhaps the most clear-cut case is, who really annoyed the Gandor mafia family, overconfidently assuming that since he could regenerate from any wound, they couldn't hurt him. So they did what the mafia does best and gave him Cement Shoes, leaving him to eternally drown at the bottom of the Hudson River until he either got dredged up or died of old age.
 * In Mahou Sensei Negima, this is the final fate of . Being annoyingly hard to keep dead and protected by several layers of barriers, devised a spell that completely froze their surroundings instead, keeping them trapped yet conscious for all eternity.
 * Near the end of Utawarerumono, the main characters enter a partially-technological dungeon and find it infested with standard-issue Slimes, which they soon get bogged down fighting - swords and arrows don't seem to do much to impede them, but on the other hand, they don't seem able to do much to harm the heroes, either. In the next episode, however, it turns out that those blobs of reddish goo are actually, and that they were transformed by the titular demon-god as punishment for   So, in the true spirit of an Utterly Pissed-Off Genie, he decides to fulfill their wish for a 'body that will never die'. And they've been there ever since. For what must be several thousand years by the time the story takes place. They deserved it, but still...
 * In Sora no Otoshimono, Chaos is defeated the first time when Ikaros sends her to the bottom of the ocean. Chaos is immortal, but the water pressure is so great that she's pinned. She eventually escapes.