Gone/WMG

Drake will do a Heel Face Turn.

 * Because one, it would throw everyone off and two, if he figured out that the Gaiaphage has no real interest in keeping him alive he would be PISSED OFF.

Either Caine or Diana will die in Light.
Okay, think about it. Caine's a pretty complex bad guy. Sometimes he's an Evil Overlord, but other times he's an Anti-Villain or even a very dark Anti-Hero. Problem is that, with a character like that, you can't just throw him in jail or whatever. But having him skip off with a happy ending would make him a total Karma Houdini, not to mention that it would be unleashing a dangerous sociopath on society. The only way to solve this would be either (a) Diana dies, reaching the last crumb of empathy he has in him, prompting him to Heel Face Turn, or (b) he dies protecting her. This will allow him to maintain his complexity while not going out-of-character, not to mention making up for his jerkassery in Plague, so the fangirls will be mollified.

Little Pete and Diana's Will connect some how.
For  is pretty powerful. When Little Pete at the end of Plague, he says how free from his stunted body he feels. However, somehow he needs to be  So how can he do it? Going back to the same body is out of the question, but an able body, not fully formed and most likely an accepting spirit? That'll do just fine. Most likely what would happen is they become a duality like the  or '
 * Jossed. At least as of Fear.

In Light, Diana will end up being the one
As of Fear, we can see that Diana. She has even turned against. In Light, Sam and the gang will definitely go after, and they do intend to. Wouldn't it just be such a sad and bitter turn of events if everyone else ended up dead/somehow incapacitated and unable to, leaving Diana to realize that there is no way to.

In Light, Astrid will
It happened before to, and as far as we know,. They might get unlucky as well. And if Sam.
 * And another WMG stemming from this one: If Astrid  during Fear, Little Pete  . He might very well need   to better fight against the gaiaphage, which now  . Plus,   would be , which could help with.
 * Unlike malnourished and assumed-infertile Diana, Astrid, so it's highly possible that this is the case.