Lunar: Eternal Blue/Tear Jerker

"Ruby: I don't want it, Hiro...I don't want eternal life!"
 * The ending, where  gets this troper every time.
 * There's a really big one at the end of Lucia's quest to find the goddess Althena. What does she find?
 * The preceding scene this sequence made This Troper realize how attached he had grown to them.
 * The entire scene where Ronfar saves Mauri.
 * The scene where Ruby has to accept the power of the Red Dragon and come to terms with the fact that she'll outlive her friends...Poor dragon-kitty.


 * Wait a second! No love for the first end?
 * The Playable Epilogue kind of subverts it, since there's a whole bunch of places you haven't explored yet after that "end", making it fairly obvious that there's more game to come.
 * Hiro's reaction alone to all of this, and especially his anguished cry as she's fading away, are enough to make you reach for the tissues by themselves. Combine them with Lucia's side of it, and you should be blubbering even before she leaves.