Oniisama e.../Tear Jerker

Being a melodramatic manga from The Seventies, Oniisama e... has a lot of tearjerking moments.

"Nanako: I... I love you! [sob]"
 * The episodes that show us Rei's broken psyche, as well as  Not to mention, there's also
 * The manga is even worse, given she completely gives up and  Specially when
 * Five words:
 * Seven more:
 * Junko Nakaya's Break the Cutie process. She seems to be a cute Ingenue, ... poor little girl.
 * Episodes 27, 28, and 29. Poor, poor  So utterly creepy in the   scene. So terribly pitiful as she breaks down more and more.
 * Aya being utterly broken (and having her reasons to be the bitch she is revealed) late in the series, ending with a suicide attempt that's barely thwarted by Nanako and Tomoko  From Jerkass Alpha Bitch to Jerkass Woobie in one, two, three...
 * In the manga, Kaoru's, especially right after seeing her happily flying off to Germany with.
 * Not to mention
 * 's Not So Stoic moment in the  arc, when she.
 * Nanako's Anguished Declaration of Love, ending with her sobbing her heart out while Rei watches, completely lost as to how to respond.