John Dies at the End/Heartwarming

"Dave: Here's the only thing you need to know about John: The reason I was surprised by your hand was because he never once described you as "the girl with only one hand.""
 * Amy is missing one of her hands, and goes on a long tangent to Dave about how everyone always treats her like a freak because of it, and always refers to her as "the girl with only one hand." Dave hadn't seen her in years, so he was surprised, but John saw her on a pretty regular basis, and talked to Dave about her pretty often.