Narc/YMMV


 * Nightmare Fuel: The final fight against Mr. Big's giant noggin. And then his giant skull. Then some giant roaches that come out his giant skull. For such an aggressively anti-drug plot, this boss fight seems to have been the direct result of someone ingesting many, many different types of mood-altering substances. Which is why its "anti-drug" message has a very tongue-in-cheek flavor.
 * What Do You Mean It Wasn't Made on Drugs?: Irony of ironies...Between the giant skull final boss, a pornographer clown, and the sheer Up to Eleven of solving drug crimes with rocket launchers (and the glittering shrapnel from blown-up enemies), it's safe to say that this trope is in effect.