Transformers Fall of Cybertron/WMG

Bumblebee's injuries in Fall of Cybertron is the reason he's mute in Prime
Assuming they're staying true to the original Word of God declaration of Transformers: War for Cybertron and Transformers Prime being in the same universe, then Bumblebee's not going to die from them. So it could be that Bumblebee's injuries in FoC might be a means to explain the more movie-esque idea of making Bumblebee mute and using sounds to communicate.

The game will involve finding other Cybertronian artifacts, such as the Key to Vector Sigma
Optimus has the Key to Vector Sigma in Transformers Prime, and WFC shows him acquiring the Matrix of Leadership. Given they are trying to escape the planet they are probably looking for everything of value they can take with them.

Guesses on who might die.
Since the game is obviously going for a Darker and Edgier apprroach might as well guess who is going to die. Don't like mine than guess your own.

Autobots:

Perceptor: Maybe the Decepticons attack a lab he is in and they kill him.

Jazz: Might end up dying against Megatron or Shockwave as a Sacrificial Lion.
 * Well, it wouldn't be the first time.

Warpath: Killed by Brawl in combat.

Metroplex: Would probably die to save Autobots.

Decepticons:

Shockwave: He's going to create the Dinobots. That probably won't end well.

Combaticons: Will probably die as Bruticus or individually.

Onslaught: Probably will end up in battle with Prime or Ironhide.

Vortex: An attempt to torture an Autobot could go south.

Brawl: Might charge headfirst into the main Autobots.

Swindle: May end up double crossing someone he shouldn't in a deal.

Blast Off: May have a large dogfight with the Arialbots.


 * Optimus Prime: Not like it wouldn't be expected. He hasn't had his inevitable death/resurrection yet in this continuity.

We will learn why Breakdown looks the way his does in Prime.
It'd just be interesting to see how he went from a coward to a brute.
 * Likely involving Shockwave experimenting on him at some point, possibly as a test subject.

We will learn why Soundwave is mute and why his design is different in Prime.

 * Jazz
 * Partly Jossed This scene happened in the trailer. In the actual gameplay (specifically in a part that happens after the trailer) Soundwave is alive and well, even speaking and telling Rumble to attack a few Autobots.
 * Jossed by Word of God. By the time of Prime, the notion is that Soundwave can talk, but just chooses not to (which is why certain characters even give him chances at speaking up, only for him to remain silent).

The Insecticons (Kickback, Hardshell, and Sharpshot) will be a Wolfpack Boss for a level where you play as a Wrecker.
The fight would leave Kickback and Sharpshot dead and Hardshell out for revenge against Wreckers. He then might hunt down and kill one in his own level.

There will be several cases of The Other Darrin in order to try and align the continuity with Prime, with other characters showing up from Prime later.
While it's clearly not happening with Ratchet or Megatron (who have kept their actor from WFC- presumably because both their Prime voice actors would be too expensive), we could hear Arcee's Prime VA show up at some stage. Some members of the Wreckers could also show up, such as Bulkhead and Wheeljack.