Dante's Inferno (video game)/WMG

Dante causes a Zombie Apocalypse
After all, he did kill Minos, Charon, and other figures who run Hell...what else would happen to the damned souls now that nobody's there to deal with them?

The citizens of the Inferno are putting up a show for Dante
Dante is clearly delirious about his own importance, asks unrelated people/things about Beatrice as if they knew. Yet none of the circle leaders (beside the obivious one) seem to note this. In the original poem, the inferno was violent but everyone minded their own business, pretty much. It is possible the circle leaders and citizens with free time are just having fun trying to defeat Dante, since he is running free around the inferno, unlike the souls judged there. It is possible after Dante leaves a circle, Reset Button is pressed.

The guy who killed Dante was really an Assassin.
He certainly has the "sneak up on people and get them In the Back" bit down. Also, why the hell not?
 * Even better, Dante's Inferno took place during one of the crusades, so it is possible that it took place during the same time as Assassin's Creed, now just think back to those templars you assassinated during the game, huh...
 * It does. Richard the Lionheart was one of the kings that fought on the Third Crusade. Bonus points for those who say in which crusade Dante fought.

The world is now thoroughly fucked
Dante kills Death. Either nobody can die now, or they do die but are now unable to reach Heaven and Hell, which means the world will soon be full of ghosts. Either way, Dante seriously broke humanity's arm punching this Cthulhu.
 * The Sequel Hook also suggests.

Alternatively, Dante didn't actually kill death
Death is a force of nature. The Grim Reaper is but one manifestation of it that exists for the convenience of our poor mortal minds. Every person who dies gets a personal Grim Reaper of their own, all extensions of the "real" Death, but while individual Reapers can be destroyed or defeated by exceptional humans, Death itself will always remain.
 * That Dante didn't kill Death was outright confirmed. Dante was experiencing an extended delusion, some bizarre application of Clap Your Hands If You Believe.

The real Big Bad is actually
...and his plans are far more elaborate than we may think... Consider how closely Dante's Inferno takes after God of War. Also consider how it turns out that, at the end of God of War, the real puppet master was. Consider that in God of War is analogous to  from Dante's Inferno. And finally, consider that we don't exactly know what's really going on yet. (For instance, what did Lucifer mean when he said that this "hell" was specifically Dante's?) Do you really think Dante will be fighting Satan as the Final Boss in the entire (potential) trilogy? I don't think so. And is it really a coincidence that and Lucifer never appear in the same scene together? Something just don't smell right about that...
 * The anime actually raises this issue, but dismisses it as Dante simply being paranoid. Because, really, what possible reason could Dante have for being paranoid of ...
 * What will joss this will be whether or not
 * As this troper recalls,

The sequel will take place in heaven.
If a sequel would be made they will continue it as to the original Divine Comedy's Paradiso.
 * It seems you forgot about Purgatorio which takes place before Paradisio and which deals exclusively with Dante's journey through the seven terrances of Purgatory. Paradisio is the third and final conclusion of Dante in Heaven.

"Death had to take him sleeping, for if Roosevelt had been awake there would have been a fight.", said a fellow politician of the time about the most badass US president ever. Except he lied.
Everybody thought Death came for Roosevelt in his sleep, but Teddie was just faking it in order to ambush Death. He then fought Death, and executed him using his own bony scythe. Realizing that he has now conquered the greatest foe on this plane of existence, he decided to take an extended leave in order to challenge hell, heaven, and possibly a few pagan pantheon realms. Right now he is using Yggdrasil as a club to beat up Fenris.
 * SOMEBODY MAKE THIS INTO A GAME NOW!!!

Dante is actually an angel.
Dante was God's best angel and Lucifer was angered over this, so he mindwiped Dante to forget everything so Lucifer could be the best angel again, after Lucifer was punished for what he done, he set up the events to get back into heaven and take over it.

The game was created by a secret society of people who know the truth as a subtle gesture of revelation.

The final boss of the game is actually
He is the last person Dante meets in the Comedy.

The final boss will be
It will be one final Secret Test of Character and not some cliched bullshit where  is actually the ultimate evil all along.
 * It could also be that is a True Neutral.

Possible paths for the 2nd and 3rd game
During the 2nd game the angels don't want Dante to enter heaven as nobody is supposed to leave Hell. So they decided to test him while he is going through Purgatory. Each of the seven terraces will have something special about them based on the sin they represent. Thus in the terrace of sloth if you stay still you take damage. Meanwhile Satan is creating several new groups of evil creatures based on the seven deadly sins. Dante assumes they are just part of the angels test. He is guided through by Matilda (she is a character in Purgatorio). The 2nd game end on a cliffhanger like God of War 2 where we pan out to see the darkness had completely overtaken Purgatorio. In the 3rd game the angels assume Dante has betrayed them and Dante has to make his way through the various celestial spheres battling both the invading forces of hell and the angelic defenders of each sphere. After Dante manages to get past both an army of Arch-Demons and Arch-Angels in the Empyrean he manages to get in the Primus Mobile where God is just as Lucifer arrives. God gives Dante power and Dante smites Lucifer out of the Empyrean. Then Dante using the stars (fixed stars are the 2nd to last celestial sphere) to fire a giant cross blast knocking back Lucifer and all the Hellish forces throughout the cosmos back to Hell. The end-game cutscene has Virgil, Matilda, and Beatrice join Dante and lead him back to the Primus Mobile to be forever within the presence of God.